whether citalopram (Celexa, etc) can be used with oral contraceptives or PPIs

January 2012

We're getting questions about whether citalopram (Celexa, etc) can be used with oral contraceptives or PPIs.

FDA recommends using lower citalopram doses when it's combined with 2C19 inhibitors, such as cimetidine or omeprazole. These can inhibit citalopram metabolism and increase the risk of QT prolongation.

This brings up questions about whether lower citalopram doses are also needed with other PPIs or oral contraceptives.

Get concise, unbiased advice for effective drug therapy, plus CE/CME

Prescriber's Letter includes:

12 issues every year, with brief articles about new meds and guidelines
48+ CE courses, including the popular CE-in-the-Letter
Quick reference drug comparison charts
Access to the entire archive

Subscribe Today!

Already a subscriber? Log in

Volume pricing available. Get a quote

Table of Contents

Vaccines who should get meningitis and shingles vaccines
Anticoagulants more emphasis on preventing bleeding due to anticoagulants in elderly patients
Women's Health higher risk of blood clots with drospirenone OCs or the contraceptive patch
COPD Arcapta (ar-CAP-ta), a new inhaled long-acting beta-agonist for COPD
Gastroenterology Rectiv (REK-tiv) will be the first low-dose nitroglycerin ointment approved for pain caused by anal fissures
Dyslipidemia whether more KIDS should be screened and treated for high cholesterol
Interactions whether citalopram (Celexa, etc) can be used with oral contraceptives or PPIs
Interactions Reps will promote Dexilant (dexlansoprazole) for patients on Plavix (clopidogrel) who need a PPI
Hypertension the best time of day to take BP meds
Osteoarthritis Patients often ask what works best for osteoarthritis pain
Cardiology You'll see ondansetron (Zofran, etc) join the list of drugs with stronger warnings about QT prolongation
Muscle Relaxants Carisoprodol (Soma, etc) will finally be a Schedule IV controlled substance in ALL states
Neurology & Pain You'll get questions about what works for essential tremor